This Research Topic is part of the Methods and Applications in Physiology series. Other titles in this series are:

• Methods and Applications in Aquatic Physiology
• Methods and Applications in Computational Physiology and Medicine
• Methods and Applications in Environmental, Aviation and Space Physiology
• Methods and Applications in Fractal Physiology
• Methods and Applications in Integrative Physiology
• Methods and Applications in Invertebrate Physiology
• Methods and Applications in Physio-logging
• Methods and Applications in Striated Muscle Physiology
• Methods and Applications in Respiratory Physiology
• Methods and Applications in Vascular Physiology
• New Methods for Red Blood Cell Research and Diagnosis, Volume II
• Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters

Introduction and general guidelines
This series aims to highlight the latest experimental techniques and methods used to understand the most fundamental questions in physiology research from molecular to organ function in living organisms. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This Topic will cover the latest advances in technologies and up-to-date methods which help advance science.

The contributions to this collection will undergo peer-review, but the criteria may be adjusted to fit the present Research Topic; for instance, while novelty is not necessarily decisive, the utility of a method or protocol must be evident. We welcome contributions covering all aspects of physiology and the submissions will be handled by the team of Topic Editors in the respective sections.

Frontiers in Physiology supports the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data management and stewardship (Wilkinson et al., Sci. Data 3:160018, 2016).

This Research Topic welcomes:
• Methods: Include either existing methods that are significantly improved or adapted for specific purposes or new methods, which may also include primary (original) data.
• Protocols: Should provide a detailed description, with pitfalls and troubleshooting, and be of immediate use to the readers. The protocols must be proven to work.
• Perspective or General Commentaries on methods and protocols relevant for physiology research.
• Reviews and mini-reviews of current methods and protocols highlighting the important future directions of the field.

For more information on the description and formats of the different article types please see here.

Clinical and Translational Physiology guidelines
Methods and Applications in Clinical and Translational Physiology welcomes contributions on new or existing methods and protocols on:
• Clinical diagnostics
e.g. sensitivity and specificity of biomarkers of distinct diseases, developments in artificial intelligence-based diagnostic support
• Clinical environmental physiology
e.g. wearable sensors, signal analysis, pattern recognition with AI, and decision making (undetected hemorrhage in acute medicine and on the battlefield)
• Clinical muscle physiology
e.g. sarcopenia in ageing and bedrest, maintenance of muscle mass measures, role of high intensity v.s. endurance training, eccentric vs. concentric muscle exercise, muscle protein synthesis and oxidative metabolism in cancer, muscle typology, fatigue and injury, maximizing training performance
• Non-invasive monitoring of cardiovascular variables
e.g. developments in non-invasive blood pressure, cardiac output)
• Vascular (cardiac, brain and peripheral arteries) ageing
e.g. Duplex ultrasound vs. plethysmographic flow-mediated vasodilation, cerebrovascular autoregulation and CO2 reactivity,
• Cardiology
e.g. transcatheter aortic valve implantation (TAVI)
• Upper airway control
e.g. sleep-disordered breathing (down to sleep-apnea)
• Aerospace medicine
e.g. models of microgravity, +G-force and maneuvers in fighter pilots,

Keywords: Clinical Physiology, Translational Physiology, Methods, Protocols, Medicine

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.