An original Asteraceae-infusion able to prevent a syndrome metabolic induced in fructose rat model: Beneficial effect of a mixture of chicoric and chlorogenic acids.

Résumé : Physiopathology of the metabolic syndrome (METS) is characterized by a self-sustaining pernicious circle, in which abdominal obesity initiates a low-grade inflammatory state and oxidative stress promoting an insulin-resistance stage and leads to diabetes of type 2. To reverse these physiological disorders, the patients must change diets and in term a pharmacological intervention is possible. Plants containing active substances with anti-inflammatory, anti-oxidative stress and anti-insulin resistance effects are great interest for phytotherapy treatment approach. The aims of our present study were to investigate the possibility to prevent METS by a chronic administration of an Asteracea infused drink (ADF) particularly reach in caffeic acid derivatives from dried dandelion leafs and root burdock. Using the model fructose rats to provoke a METS in eight weeks we have daily administrated to a rats cohort the Asteraceae infusion-drink (500 mg/kg daily) vs rats cohort having received the fructose diet. We have also a control cohort fed with a conventional diet and a fructose-group was treated by metformin (100 mg/kg daily) as a positive drug control. Physiological parameters (weight of animals, blood glucose levels, triglyceride and cholesterol) were carried out during the experiment and an insulin tolerance test and glucose tolerance test were made at 8th week. Result show that chronic supplementation with ADF induce significative effects on animal weight, glucose tolerance and insulin sensitivity.

Mots clés : Metabolic syndrome, phytotherapy, Asteraceae, burdock, dandelion, fructose model rats.

Auteurs : Arezki Yanis Idres, Didier Tousch , Karine Portet , Karine Ferrare, Luc. P. R. Bidel et Patrick Poucheret

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