Is QoL correlated to impairment of respiratory function in post COVID 19 pneumonia patients?

Résumé :
Introduction : It is admitted that COVID19 pneumonia (C-19P) can impair respiratory function which could impact patient’s Quality of Life (QoL). Thus, our objective was to look for eventual correlations between QoL and respiratory
function after recovering from C-19P.
Patients and methods : Our prospective study involved 177 C-19P patients, 3 to 6 months after recovery. Respiratory function wasassessed by spirometry and DLCO measurement. QoL was assessed by SF-12 and NHP scales.
Results : Ventilatory defect was revealed by abnormal spirometry in 17% with restrictive profile confirmed by decreased
TLC in 11.9 % and obstructive profile in 5.1%. Gaz exchange Impairment was revealed by DLCO decrease in 40.7%.
QoL was altered as revealed by SF12 and NHP scales. The mean SF-12 physical score(39%) was positively
correlated to FEV1(p=0.041; r = 0.154) and TLC(p=0.010; r=0.199). The mean SF-12 mental score(50.73%)
was also positively correlated to FEV1(p=0.020; r= 0.174) and TLC(p=0.009; r=0.202).
NHP mean score out of 100 points was distributed as follows: 34 for lack of energy, 20 for pain, 18 for sleep
disturbance, 18 for exaggerated emotional reactions, 17 for mobility limitation and 13 for social isolation.
Among these dimensions, only pain, energy lack and mobility limitation were negatively correlated to FEV1
and TLC(p <0.005; -0.271).
However, no correlations were found between QoL scales and DLCO decrease.
Conclusion : In the light of our results, we can conclude that restrictive ventilatory defect caused by C-19P have a negative impact on QoL of patients even months after the onset of the disease

Mots clés : COVID-19; QoL; Respiratory function 


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